Difference between revisions of "Imipramine-escitalopram"
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| − | + | {{Drugswitch | |
| + | | from = imipramine | ||
| + | | to = escitalopram | ||
| + | | stop = | ||
| + | * '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day. | ||
| + | * '''Day 1:''' reduce dosage of imipramine to 50 mg/day. | ||
| + | * '''Day 3:''' reduce dosage of imipramine to 25 mg/day. | ||
| + | * '''Day 8:''' stop administration of imipramine. | ||
| + | | start = | ||
| + | * '''Day 1:''' simultaneously start administration of escitalopram in a normal dosage of 10 mg/day. | ||
| + | | info = | ||
| + | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
| + | * Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes imipramine. | ||
| + | * {{theorSS}} | ||
| + | }} | ||
Revision as of 23:34, 4 March 2010
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Switch medication from imipramine to escitalopram.[1] [2]
Stop imipramine - Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/day.
- Day 1: reduce dosage of imipramine to 50 mg/day.
- Day 3: reduce dosage of imipramine to 25 mg/day.
- Day 8: stop administration of imipramine.
Start escitalopram- Day 1: simultaneously start administration of escitalopram in a normal dosage of 10 mg/day.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes imipramine.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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