Difference between revisions of "Combining-Topiramate-Olanzapine"
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Revision as of 11:35, 5 March 2010
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Adding risperidone to topiramate.
General information- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start risperidone- Start olanzapine according general dosing advice.
Cave- Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. [5]
- ↑ 1.0 1.1 Farmacotherapeutisch Kompas - topiramaat (dutch)
- ↑ 2.0 2.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 4.0 4.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Drugs.com risperidone
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