Difference between revisions of "Fluoxetine-bupropion"
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Switch medication from fluoxetine to bupropion.[1] [2]
Stop fluoxetine - Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- When a dosage of 20 mg/day is reached, stop administration.
Start bupropion- Day 1: no administration of fluoxetine and bupropion (“wash-out” period of one day).
- Day 2: start administration of bupropion in a low dosage of 150 mg/2 days (every other day).
- Day 8: continue administration of bupropion is normal dosage of 150 mg/day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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