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{{Drugcombi
| base = Carbamazepinecarbamazepine| add = Olanzapinerisperidone
| info =
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
| start =
* Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. Add olanzapine according to Coadministration with carbamazepine may decrease the general dosing advice plasma concentrations of risperidone and increase dose based on clinical effect or serum concentration. <ref name=”medicatiebewaking”> Schalekamp T. et alits pharmacologically active metabolite, Interacties met Psychofarmaca, Stichting Health Base, Houten, 20029-hydroxyrisperidone. </ref> <ref name=”levyrh”> Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000* Risperidone should be given at higher dosage to control psychotic symptoms. </ref> <ref name=”bazire”"drugscom"> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. {{Drugscominteract|risperidone-with-carbamazepine|risperidone|carbamazepine}}</ref>
| cave =
* Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. <ref name="aricarb"> {{Pubmed|19934718|Strack DK et al. Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine. J Psychiatr Pract. 2009 Nov;15(6):442-8}}</ref>
}}
