Difference between revisions of "Bupropion-dosulepine"
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Switch medication from bupropion to dosulepine.[1] [2]
Stop bupropion - Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- When a dosage of 150 mg/day is reached, stop administration.
Start dosulepine- Day 1-3: start administration of dosulepine the next day in a low dosage of 50 mg/day.
- Day 4: increase dosage of dosulepine to 75 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
More information- Bupropion slows the metabolism of dosulepine by CYP2D6.
- Caution is necessary at the start of administration of dosulepine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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