Difference between revisions of "Bupropion-paroxetine"
From Psychiatrienet
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| − | * | + | * By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. |
| + | * Bupropion slows the metabolismof paroxetine by CYP2D6.}} | ||
Revision as of 12:13, 4 May 2009
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Switch medication from bupropion to paroxetine.[1] [2]
Stop bupropion - Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- When a dosage of 150 mg/day is reached, stop administration.
Start paroxetine- No wash-out period is needed.
- Start paroxetine the next day in low dosage of 10 mg/day.
More information- By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
- Bupropion slows the metabolismof paroxetine by CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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