Difference between revisions of "Vortioxetine-agomelatine"

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{{Drugswitch
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| from = Vortioxetine
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| to = agomelatine
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{{downVenla}}
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* '''Day 7:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.  
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* '''Day 15:''' continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
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Revision as of 15:56, 18 February 2015

Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from Vortioxetine to agomelatine.[1] [2]

Nietinrijdenbord.png Stop Vortioxetine
  • Day 1-14: gradually reduce dosage of venlafaxine to a maximum of 37,5 mg or 75 mg (slow release)/ day.
  • Day 15: stop administration of venlafaxine
Eenrichtingbord.png Start agomelatine
  • Day 7: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
  • Day 15: continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.[3]


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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