Difference between revisions of "Duloxetine-vortioxetine"
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− | + | {{Drugswitch | |
+ | | from = duloxetine | ||
+ | | to = vortioxetine | ||
+ | | stop = | ||
+ | * '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day. | ||
+ | * '''Day 1-7:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day | ||
+ | * '''Day 8-14:''' reduce dosage of duloxetine to 30 mg/day to 0 mg/day | ||
+ | * '''Day 15:''' stop administration of duloxetine. | ||
+ | | start = | ||
+ | * A wash-out period is not necessary. | ||
+ | * '''Day 15:''' Start administration of vortioxetine the next day in a dosage of 10 mg/day. | ||
+ | | info = | ||
+ | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
+ | }} |
Revision as of 14:48, 4 March 2015
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Switch medication from duloxetine to vortioxetine.[1] [2]
- Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day.
- Day 1-7: reduce dosage of duloxetine from 60 mg/day to 30 mg/day
- Day 8-14: reduce dosage of duloxetine to 30 mg/day to 0 mg/day
- Day 15: stop administration of duloxetine.
- A wash-out period is not necessary.
- Day 15: Start administration of vortioxetine the next day in a dosage of 10 mg/day.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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