Difference between revisions of "Chlorpromazine-Lurasidone"
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Switch medication from Chlorpromazine to Lurasidon.[1] [2]
Stop Chlorpromazine - Day 1-7: gradually reduce the dose of chlorpromazine to 50% of the dose.
- Day 8-14: gradually reduce the dose of chlorpromazine to 0% of the dose
- Day 14: stop administration of chlorpromazine.
Start Lurasidon- Day 1-7: start administration of lurasidon in a dose of 40 mg/day.
- Day 8-14: increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
More information- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[3]
- It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. [4]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
- ↑ McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.
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