Difference between revisions of "Duloxetine-trazodone"
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Switch medication from duloxetine to trazodone.[1] [2]
Stop duloxetine - Day 0: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day.
- Day 1-7: reduce a dosage of 60 mg/day to 30 mg/day.
- Day 8: stop administration of duloxetine.
Start trazodone- Day 9: start administration of trazodone in a low dosage of 150 mg/day.
More information- Duloxetine slows the metabolism of trazodone via CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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