Difference between revisions of "Aripiprazole LA-Clozapine"
From Psychiatrienet
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| to = clozapine | | to = clozapine | ||
| stop = {{Lastinjection}} | | stop = {{Lastinjection}} | ||
| − | | start = {{Startslweeks | + | | start = |
| + | * '''Day 1:''' Start witch 12,5 mg | ||
| + | * '''Next weeks: ''' increase with step of 25 mg | ||
| + | {{Startslweeks}} | ||
| info = {{SPCaripiprazoleLA}} | | info = {{SPCaripiprazoleLA}} | ||
| view = StopDepotStartOral.jpg | | view = StopDepotStartOral.jpg | ||
}} | }} | ||
Revision as of 17:14, 16 March 2015
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Switch medication from Aripiprazole LA to clozapine.[1] [2]
Stop Aripiprazole LA - Day 1: Last depot injection
Start clozapine- Day 1: Start witch 12,5 mg
- Next weeks: increase with step of 25 mg
- Week 1-3: approx. 25% of target dose
- Week 4-6: approx. 50% of target dose
- Week 7-9: approx. 75% of target dose
- Week 10: target dose
More information- More information you'll find in the summary of product characteristics (SPC) of aripiprazole depot injection. [3]
— Aripiprazole LA — clozapine
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002755/WC500156111.pdf SPC of the European Medicines Agency on aripiprazole depot
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