Difference between revisions of "Olanzapine-Lurasidone"

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{{Drugswitch  
 
{{Drugswitch  
 
| from = Olanzapine
 
| from = Olanzapine
| to = Lurasidon
+
| to = Lurasidone
| stop =  
+
| stop = {{StopStand}}
* '''Day 1-7:''' gradually reduce the dose of olanzapine to 50% of the dose.
+
| start = {{StartStand}}
* '''Day 8-14:''' gradually reduce the dose of olanzapine to 0% of the dose
+
| info =  
* '''Day 14:''' stop administration of olanzapine.
+
{{RefSwitchToLurasidone}}
| start =  
+
| view = switchstandaardup en down.jpg
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
 
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable. 
 
| info = {{caveQT}}
 
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
 
 
}}
 
}}

Latest revision as of 12:01, 22 March 2015

Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Lurasidone
Type Antipsychotic
Group Atypical AP
links
Medscape Lurasidone
PubMed Lurasidone
Kompas (Dutch) Lurasidone
Wikipedia Lurasidone

Switch medication from Olanzapine to Lurasidone.[4] [5]

Nietinrijdenbord.png Stop Olanzapine
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Lurasidone
  • Day 1-4: approx. 25% of target dose
  • Day 5-8: approx. 50% of target dose
  • Day 9-12: approx. 75% of target dose
  • Day 13: target dose
Infobord.png More information
  • More information on switching to lurasidon: see reference. [6]
    Switchstandaardup en down.jpg
Nietinrijdenbord.png — Olanzapine
Eenrichtingbord.png — Lurasidone


  1. 1.0 1.1 1.2 1.3 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch)
  2. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  4. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  5. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  6. McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.
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