Changes

* Administration '''Day 1-14:'''Gradually decrease the dosage of hypericum. * '''Day 15:''' stop administration of hypericum can be stopped abruptly.| start = * '''Day 115-722:''' a wash-out period of one week is necessary.* '''Day 823:''' start administration of mirtazapine in a dosage of 15 mg/day.* '''Day 1530:''' increase dosage of mirtazapine to 30 mg/day.

* Occurrence of the serotonin syndrome is theoretically possible.{{nointeractions}}* Hypericum slows the metabolism of citalopram/escitalopram via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.}}