| from = citalopram
| to = hypericum
| stop = * '''Before day 0:''' gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/day, resp. 10 mg/day. * '''Day 1:''' reduce dosage of citalopram/escitalopram to 10 mg/day, resp. 5 mg/day.* '''Day 8:''' stop administration of citalopram/escitalopram.{{stopCitalopram14d}}
| start =
* '''Day 8-14:''' a wash-out period of one week is necessary.* '''Day 1516:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref><ref name="informatorium">{{KNMP|citalopram}}</ref> {{Lit-SSRI-Hypericum}} {{Lit-SSRI-Hypericum2}} | caveat = {{SSRI14d}}
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Hypericum slows the metabolism of citalopram/escitalopram via CYP3A4. {{HypericumInfo}}}}
