Difference between revisions of "Bupropion-clomipramine"
From Psychiatrienet
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* '''Day 4:''' increase dosage of clomipramine to 75 mg/day and continue slowly increasing the dosage depending on the condition of the patient. | * '''Day 4:''' increase dosage of clomipramine to 75 mg/day and continue slowly increasing the dosage depending on the condition of the patient. | ||
| info = | | info = | ||
| − | * Bupropion slows the metabolism of clomipramine | + | * Bupropion slows the metabolism of clomipramine via CYP2D6. |
* Caution is necessary at the start of administration of clomipramine. }} | * Caution is necessary at the start of administration of clomipramine. }} | ||
Revision as of 21:15, 5 May 2009
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Switch medication from bupropion to clomipramine.[1] [2]
Stop bupropion - Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- When a dosage of 150 mg/day is reached, stop administration.
Start clomipramine- Day 1-3: start administration of clomipramine the next day in a low dosage of 25-50 mg/day.
- Day 4: increase dosage of clomipramine to 75 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
More information- Bupropion slows the metabolism of clomipramine via CYP2D6.
- Caution is necessary at the start of administration of clomipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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