Difference between revisions of "Escitalopram-fluoxetine"
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Revision as of 15:09, 21 October 2015
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Switch medication from escitalopram to fluoxetine.[1] [2]
Stop escitalopram - Gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day.
- When a dosage of 10 mg/day, is reached, stop administration.
Start fluoxetine- No wash-out period is needed.
- Start fluoxetine the next day in normal dosage of 20 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluoxetine slows the metabolism of escitalopram by inhibition of CYP2C19, CYP2D6 and CYP3A4
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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