Difference between revisions of "Citalopram-fluoxetine"
From Psychiatrienet
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| from = citalopram | | from = citalopram | ||
| to = fluoxetine | | to = fluoxetine | ||
| − | | stop = {{ | + | | stop = {{StopCitalopram}} |
| start = | | start = | ||
* No wash-out period is needed. | * No wash-out period is needed. | ||
Revision as of 08:54, 28 October 2015
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Switch medication from citalopram to fluoxetine.[1] [2]
Stop citalopram - Before day 1: gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
- Day 1: reduce dosage of citalopram to a maximum of 10 mg/day.
- Day 8: stop administration of citalopram
Start fluoxetine- No wash-out period is needed.
- Start fluoxetine the next day in normal dosage of 20 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluoxetine slows the metabolism of citalopram by inhibition of CYP2C19, CYP2D6 and CYP3A4
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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