Difference between revisions of "Tranylcypromine-hypericum"
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Switch medication from tranylcypromine to hypericum.[1] [2]
Stop tranylcypromine - Day 1: decrease the original dose with about 25% every 3 days.
- Day 9: stop administration of tranylcypromine.
Start hypericum- Day 15: Start and increase the dose with about 25% of the target dose every 3 days or 50% per week.[3][4][5]
More information- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.
- ↑ Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
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