Difference between revisions of "Paroxetine-nortriptyline"
From Psychiatrienet
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| to = nortriptyline | | to = nortriptyline | ||
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| − | {{ | + | {{stopParoxetine}} |
| start = | | start = | ||
| − | * '''Day | + | * '''Day 9:''' start administration of nortriptyline in a low dosage of 25 mg/day. |
| − | * '''Day | + | * '''Day 16:''' continue nortriptyline in a dosage of 50 mg/day. |
| info = | | info = | ||
* Paroxetine slows the metabolism of nortriptyline via CYP2D6. | * Paroxetine slows the metabolism of nortriptyline via CYP2D6. | ||
| − | |||
}} | }} | ||
Revision as of 14:13, 28 October 2015
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Switch medication from paroxetine to nortriptyline.[1] [2]
Stop paroxetine - Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
- Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
- Day 8: stop administration of paroxetine.
Start nortriptyline- Day 9: start administration of nortriptyline in a low dosage of 25 mg/day.
- Day 16: continue nortriptyline in a dosage of 50 mg/day.
More information- Paroxetine slows the metabolism of nortriptyline via CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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