Difference between revisions of "Nortriptyline-tranylcypromine"
From Psychiatrienet
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| − | * '''Day | + | * '''Day 9-15:''' a wash-out period of one week is necessary. |
| − | * '''Day | + | * '''Day 16:''' start administration of tranylcypromine in a low dosage of 20 mg/day for one week. |
| − | * '''Day | + | * '''Day 23:''' after this week the dosage of tranylcypromine can be increased if necessary. |
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Revision as of 15:24, 28 October 2015
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Switch medication from nortriptyline to tranylcypromine.[1] [2]
Stop nortriptyline - Before day 1: gradually reduce dosage of nortriptyline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- Day 1-3: reduce dosage of nortriptyline to 25 mg/day.
- Day 4-7: reduce dosage of nortriptyline to 10 mg/day.
- Day 8: stop administration of nortriptyline.
Start tranylcypromine- Day 9-15: a wash-out period of one week is necessary.
- Day 16: start administration of tranylcypromine in a low dosage of 20 mg/day for one week.
- Day 23: after this week the dosage of tranylcypromine can be increased if necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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