Difference between revisions of "Amitriptyline-moclobemide"
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Revision as of 16:28, 28 October 2015
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Switch medication from amitriptyline to moclobemide.[1] [2]
Stop amitriptyline - Before day 1: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
- Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
- Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
- Day 8: stop administration of amitriptyline.
Start moclobemide- Day 8-21: a wash-out period of about 2 weeks is necessary.
- Day 22: start administration of moclobemide in a dosage of 150 mg/day.
- Day 28: increase dosage of moclobemide to 300 mg/day or more.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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