Difference between revisions of "Dosulepine-citalopram"
From Psychiatrienet
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
* Citalopram is a weak inhibitor of CYP2D6, which metabolizes dosulepine. | * Citalopram is a weak inhibitor of CYP2D6, which metabolizes dosulepine. | ||
| + | {{review}} | ||
}} | }} | ||
Revision as of 16:50, 28 October 2015
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Switch medication from dosulepine to citalopram.[1] [2]
Stop dosulepine - Before day 1: gradually reduce dosage of dosulepine to a maximum of 75 mg/day.
- Day 1: reduce dosage of dosulepine to 50 mg/day.
- Day 3: reduce dosage of dosulepine to 25 mg/day.
- Day 7: stop dosulepine
Start citalopram- Day 8: start administration of citalopram in a normal dosage of 20 mg/day.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Citalopram is a weak inhibitor of CYP2D6, which metabolizes dosulepine.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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