Difference between revisions of "Amitriptyline-duloxetine"
From Psychiatrienet
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| − | * '''Day | + | * '''Day 9-15:''' a wash-out period of one week is necessary. |
| − | * '''Day | + | * '''Day 16:''' start administration of duloxetine in a normal dosage of 60 mg/day. |
| info = | | info = | ||
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* Duloxetine is an inhibitor of CYP2D6, which metabolizes amitriptyline. | * Duloxetine is an inhibitor of CYP2D6, which metabolizes amitriptyline. | ||
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Revision as of 13:01, 2 November 2015
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Switch medication from amitriptyline to duloxetine.[1] [2]
Stop amitriptyline - Before day 1: gradually reduce dosage of amitriptyline to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
- Day 1: reduce dosage of amitriptyline to 50 mg/day.
- Day 8: reduce dosage of amitriptyline to 25 mg/day.
- Day 15: stop administration of amitriptyline.
Start duloxetine- Day 9-15: a wash-out period of one week is necessary.
- Day 16: start administration of duloxetine in a normal dosage of 60 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Duloxetine is an inhibitor of CYP2D6, which metabolizes amitriptyline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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