Difference between revisions of "Dosulepine-imipramine"
From Psychiatrienet
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* No wash-out period is needed. | * No wash-out period is needed. | ||
| − | * | + | * ''' Day 9: ''' start administration of imipramine in a normal dosage of 50-100 mg/day. |
| info = | | info = | ||
* {{TCAantichol}} | * {{TCAantichol}} | ||
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Revision as of 13:19, 2 November 2015
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Switch medication from dosulepine to imipramine.[1] [2]
Stop dosulepine - Before day 1: gradually reduce dosage of dosulepine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
- Day 1-3: reduce dosage of dosulepine to 50 mg/day.
- Day 4-7: reduce dosage of dosulepine to 25 mg/day.
- Day 8: stop administration of dosulepine.
Start imipramine- No wash-out period is needed.
- Day 9: start administration of imipramine in a normal dosage of 50-100 mg/day.
More information- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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