Difference between revisions of "Doxepine-escitalopram"
From Psychiatrienet
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* '''Day 1:''' simultaneously start administration of escitalopram in a normal dosage of 10 mg/day. | * '''Day 1:''' simultaneously start administration of escitalopram in a normal dosage of 10 mg/day. | ||
| info = | | info = | ||
| − | * | + | * {{theorSS}} |
* Escitalopram is a weak inhibitor of CYP2D6, which metabolizes doxepin. | * Escitalopram is a weak inhibitor of CYP2D6, which metabolizes doxepin. | ||
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Revision as of 13:23, 2 November 2015
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Switch medication from doxepin to escitalopram.[2] [3]
Stop doxepin - Before day 1: gradually reduce dosage of doxepin to a maximum of 100 mg/day.
- Day 1: reduce dosage of doxepin to 50 mg/day.
- Day 3: reduce dosage of doxepin to 25 mg/day.
- Day 8: stop administration of doxepin.
Start escitalopram- Day 1: simultaneously start administration of escitalopram in a normal dosage of 10 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Escitalopram is a weak inhibitor of CYP2D6, which metabolizes doxepin.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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