Difference between revisions of "Vortioxetine-tranylcypromine"
From Psychiatrienet
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* '''Day 8-21:''' a wash-out period of two weeks is necessary. | * '''Day 8-21:''' a wash-out period of two weeks is necessary. | ||
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* '''Day 29:''' after this week the dosage of tranylcypromine can be increased if necessary. | * '''Day 29:''' after this week the dosage of tranylcypromine can be increased if necessary. | ||
| caveat = | | caveat = | ||
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Revision as of 10:04, 4 November 2015
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Switch medication from vortioxetine to tranylcypromine.[1] [2]
Stop vortioxetine - Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
Start tranylcypromine- Day 8-21: a wash-out period of two weeks is necessary.
- Day 22: Start administration of tranylcypromine in low dosage of 20 mg/day for one week.
- Day 29: after this week the dosage of tranylcypromine can be increased if necessary.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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