Difference between revisions of "Venlafaxine-agomelatine"
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− | + | * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day. | |
− | | | + | * '''Day 8:''' continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref> |
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Revision as of 11:42, 4 November 2015
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Switch medication from venlafaxine to agomelatine.[1] [2]
- Before day 1: gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
- Day 1: reduce a dosage of 75 mg/day to 37,5 mg/day.
- Day 8: stop administration of venlafaxine.
- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
- Day 8: continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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