Difference between revisions of "Clomipramine-paroxetine"
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| − | * '''Day | + | * '''Day 9:''' start administration of paroxetine in a normal dosage of 20 mg/day. |
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* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes clomipramine. | * Paroxetine is a strong inhibitor of CYP2D6, which metabolizes clomipramine. | ||
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Latest revision as of 12:02, 4 November 2015
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Switch medication from clomipramine to paroxetine.[1] [2]
Stop clomipramine - Before day 1: gradually reduce dosage of clomipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
- Day 1-3: reduce dosage of clomipramine to 50 mg/day.
- Day 4-7: reduce dosage of clomipramine to 25 mg/day.
- Day 8: stop administration of clomipramine.
Start paroxetine- Day 9: start administration of paroxetine in a normal dosage of 20 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes clomipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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