Difference between revisions of "Imipramine-bupropion"
From Psychiatrienet
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* '''Day 4-7:''' reduce dosage of imipramine to 25 mg/day. | * '''Day 4-7:''' reduce dosage of imipramine to 25 mg/day. | ||
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| − | * '''Day 1:''' | + | * '''Day 1:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of imipramine according to the scheme above. |
| − | + | * '''Day 8:''' stop administration of imipramine and continue administration of bupropion only in a dosage of 300 mg/day. | |
| − | |||
| − | * '''Day 8:''' | ||
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| − | |||
| info = | | info = | ||
* Bupropion is a strong inhibitor of CYP2D6, which metabolizes imipramine. }} | * Bupropion is a strong inhibitor of CYP2D6, which metabolizes imipramine. }} | ||
Revision as of 08:28, 6 May 2009
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Switch medication from imipramine to bupropion.[1] [2]
Stop imipramine - Before day 0: gradually reduce dosage of imipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
- Day 1-3: reduce dosage of imipramine to 50 mg/day.
- Day 4-7: reduce dosage of imipramine to 25 mg/day.
Start bupropion- Day 1: simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of imipramine according to the scheme above.
- Day 8: stop administration of imipramine and continue administration of bupropion only in a dosage of 300 mg/day.
More information- Bupropion is a strong inhibitor of CYP2D6, which metabolizes imipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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