Difference between revisions of "Moclobemide-bupropion"
From Psychiatrienet
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* '''Day 1-2:''' a wash-out period of two days is necessary. | * '''Day 1-2:''' a wash-out period of two days is necessary. | ||
| − | * '''Day 3:''' start bupropion after this period in a normal dosage of 150 mg/day.}} | + | * '''Day 3:''' start bupropion after this period in a normal dosage of 150 mg/day. |
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| + | * Occurence of the serotonin syndrome is theoretically possible.}} | ||
Revision as of 08:40, 6 May 2009
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Switch medication from moclobemide to bupropion.[1] [2]
Stop moclobemide - Gradually reduce dosage of moclobemide to a maximum of 300 mg/ day.
- When a dosage of 300 mg/day is reached, stop administration.
Start bupropion- Day 1-2: a wash-out period of two days is necessary.
- Day 3: start bupropion after this period in a normal dosage of 150 mg/day.
More information- Occurence of the serotonin syndrome is theoretically possible.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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