Difference between revisions of "Amitriptyline-moclobemide"
From Psychiatrienet
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* '''Day 8-21:''' a wash-out period of about 2 weeks is necessary. | * '''Day 8-21:''' a wash-out period of about 2 weeks is necessary. | ||
Revision as of 13:07, 16 June 2016
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Switch medication from amitriptyline to moclobemide.[1] [2]
Stop amitriptyline - Day 1: Decrease with about 25% of the original dose per 3 days.
- Stop and wait 7 days for washout
Start moclobemide- Day 8-21: a wash-out period of about 2 weeks is necessary.
- Day 22: start administration of moclobemide in a dosage of 150 mg/day.
- Day 28: increase dosage of moclobemide to 300 mg/day or more.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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