Difference between revisions of "Fluoxetine-tranylcypromine"
From Psychiatrienet
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| caveat = | | caveat = | ||
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Revision as of 13:11, 20 June 2016
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Switch medication from fluoxetine to tranylcypromine.[1] [2]
Stop fluoxetine - Decrease with about 25% of original dose every 3 days
- wait for 5-6 weeks for washout
Start tranylcypromine- Start at the first day after the washout period of 5-6 weeks with about 25% of target dose.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
More information- Desmethylfluoxetine has a half live of about one week so a long wash-out period is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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