Difference between revisions of "Mirtazapine-fluvoxamine"
From Psychiatrienet
| Line 5: | Line 5: | ||
{{stopMirtazapine}} | {{stopMirtazapine}} | ||
| start = | | start = | ||
| − | {{ | + | {{startFluvoxamine}} |
| info = | | info = | ||
* Fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4. | * Fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4. | ||
{{lowlevels}} | {{lowlevels}} | ||
}} | }} | ||
Revision as of 13:58, 14 October 2021
| ||||||||||||||||||||||
| ||||||||||||||||||||||
Switch medication from mirtazapine to fluvoxamine.[1] [2]
Stop mirtazapine - Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
- Day 1: Reduce dosage of mirtazapine to 15 mg/day.
- Day 8: Stop administration of mirtazapine.
Start fluvoxamine
More information- Fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4.
- Pharmacokinetic interaction is not important because of low plasma levels.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
