Difference between revisions of "Mirtazapine-fluvoxamine"

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| to = fluvoxamine
 
| to = fluvoxamine
 
| stop =  
 
| stop =  
* '''Day 0:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
+
{{stopMirtazapine}}
* '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day.
+
| start =
* '''Day 8:''' stop administration of mirtazapine.
+
* No wash-out period is needed.  
| start = 
+
* '''Day 9: ''' start fluvoxamine in normal dosage of 50 mg/day.
* '''Day 8:''' start fluvoxamine in a normal dosage of 50 mg/day.
+
|  
* If necessary, increase dosage of fluvoxamine to 50-100 mg/day.  
+
}}
| info =
 
* Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4.}}
 

Latest revision as of 09:11, 29 October 2021

Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine
Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine

Switch medication from mirtazapine to fluvoxamine.[1] [2]

Nietinrijdenbord.png Stop mirtazapine
  • Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
  • Day 1: Reduce dosage of mirtazapine to 15 mg/day.
  • Day 8: Stop administration of mirtazapine.
Eenrichtingbord.png Start fluvoxamine
  • No wash-out period is needed.
  • Day 9: start fluvoxamine in normal dosage of 50 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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