Difference between revisions of "Amisulpride-Penfluridol"

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Revision as of 16:05, 18 March 2022

Penfluridol
Type Antipsychotic
Group Atypical AP
links
PubMed Penfluridol
Wikipedia Penfluridol
Amisulpride
Type Antipsychotic
Group Atypical AP
links
PubChem 2159
PubMed Amisulpride
Wikipedia Amisulpride

Switch medication from Penfluridol to Amisulpride.[1] [2]

Nietinrijdenbord.png Stop Penfluridol
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Amisulpride
  • Week 1: start with 10 mg
  • Week 2: increase dose to 20 mg
  • Week 3 and further: adjust dose according to clinical presentation
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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