Difference between revisions of "Vortioxetine-sertraline"

From Psychiatrienet
Jump to: navigation, search
Line 2: Line 2:
 
| from = vortioxetine  
 
| from = vortioxetine  
 
| to = sertraline
 
| to = sertraline
| stop =  
+
| stop = {{StopSSRI,SNRI}}
{{stopVortioxetine}}
+
| start = {{StartAntidepressant}}
| start =  
+
| info =
* ''' Day 8-14: ''' a wash-out period of 1 week is necessary, because of CYP2D6-inhibition and serotonergic actions. <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref>
+
* Safe target dose sertraline = 50 mg
* '''Day 15:''' Start sertraline in a normal dosage of 50 mg/day.
 
| info =
 
 
* {{theorSS}}
 
* {{theorSS}}
* Sertraline is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}
 

Revision as of 17:08, 24 February 2023

{{Drugswitch | from = vortioxetine | to = sertraline | stop =

  • Day 1: Decrease dose to 50%
  • Day 8: Stop

| start =

  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary

| info =

  • Safe target dose sertraline = 50 mg
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.