Difference between revisions of "Agomelatine-imipramine"
From Psychiatrienet
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| from = agomelatine | | from = agomelatine | ||
| to = imipramine | | to = imipramine | ||
| − | | stop = | + | | stop = {{StopAgomelatine}} |
| − | |||
| start = | | start = | ||
| − | * Start administration of imipramine | + | * '''Day 2: '''Start administration of imipramine in a dosage of 25-75 mg/day. |
| − | * If necessary, increase | + | * If necessary, gradually increase the dose with about 25% of the target dose every 3 days. |
| + | * Therapeutic Drug Monitoring of imipramine is useful, especially during the build up phase. Blood sampling is possible when reaching a steady state with the same dose after one week. | ||
| + | |||
| + | |info = | ||
| + | * A wash-out period is not necessary. | ||
| + | |||
| + | }} | ||
Latest revision as of 17:19, 24 February 2023
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Switch medication from agomelatine to imipramine.[1] [2]
Stop agomelatine - Day 1: Stop agomelatine.
- Agomelatine can be stopped abruptly for every dosage.[3]
Start imipramine- Day 2: Start administration of imipramine in a dosage of 25-75 mg/day.
- If necessary, gradually increase the dose with about 25% of the target dose every 3 days.
- Therapeutic Drug Monitoring of imipramine is useful, especially during the build up phase. Blood sampling is possible when reaching a steady state with the same dose after one week.
More information- A wash-out period is not necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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