Difference between revisions of "Amitriptyline-duloxetine"
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{{Drugswitch | {{Drugswitch | ||
| from = amitriptyline | | from = amitriptyline | ||
| − | | to = duloxetine | + | | to = duloxetine |
| stop = | | stop = | ||
| − | + | {{TCAdecrease25p3d}} | |
| − | + | | start = {{StartAntidepressant}} | |
| − | + | | info = | |
| − | | start = | + | * Safe target dose duloxetine = 60 mg |
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| − | * | ||
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}} | }} | ||
Latest revision as of 10:53, 30 June 2023
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Switch medication from amitriptyline to duloxetine.[1] [2]
Stop amitriptyline - Day 1: Decrease with about 25% of the original dose per 3 days.
Start duloxetine- Day 1: Start with 50% of the target dose
- Day 8: Increase dose to 100% of the target dose
- Day 9 and after: Gradually increase dose as necessary
More information- Safe target dose duloxetine = 60 mg
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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