| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.* '''Day 3:''' reduce dosage of clomipramine to 10 mg/day.* '''Day 8:''' stop administration of clomipramine.{{TCAdecrease25p3d}}| start = * A wash-out period is not necessary.* '''Day 8:''' start administration of vortioxetine in a dosage of 5 mg/day.* '''Day 22:''' increase dosage of vortioxetine.{{StartAntidepressant}}| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose vortioxetine = 10 mg
}}
