Difference between revisions of "Dosulepine-sertraline"

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| to = sertraline  
 
| to = sertraline  
 
| stop =  
 
| stop =  
* '''Before day 0:''' gradually reduce dosage of dosulepine to a maximum of 75 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of dosulepine to 50 mg/day.
+
| start = {{StartAntidepressant}}
* '''Day 3:''' reduce dosage of dosulepine to 25 mg/day.
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| info =
* '''Day 7:''' stop administration of dosulepine.
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* Safe target dose sertraline = 50 mg
| start =  
+
 
* '''Day 8:''' start administration of sertraline in a normal dosage of 50 mg/day.
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}}
* '''Day 22:''' if necessary increase dosage of sertraline to 100 mg/day.
 
| info =
 
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 
* Sertraline is a weak inhibitor of CYP2D6, which metabolizes dosulepine.  }}
 

Latest revision as of 11:13, 30 June 2023

dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from dosulepine to sertraline.[1] [2]

Nietinrijdenbord.png Stop dosulepine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start sertraline
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose sertraline = 50 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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