Difference between revisions of "Doxepine-mirtazapine"

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(Created page with '{{Drugswitch | from = doxepin | to = mirtazapine | stop = * '''Before day 0:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day. * '''Day 1:''' reduce dosage of...')
 
 
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| to = mirtazapine  
 
| to = mirtazapine  
 
| stop =  
 
| stop =  
* '''Before day 0:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of doxepin to 50 mg/day.
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| start = {{StartAntidepressant}}
* '''Day 3:''' reduce dosage of doxepin to 25 mg/day.
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| info =
| start =  
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* Safe target dose mirtazapine = 15 mg
Caution is necessary.
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}}
* '''Day 1:''' simultaneously start administration of mirtazapine in a normal dosage of 30 mg/day.
 
* '''Day 8:''' stop administration of doxepin and continue administration of mirtazapine.}}
 

Latest revision as of 11:17, 30 June 2023

Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin
Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine

Switch medication from doxepin to mirtazapine.[2] [3]

Nietinrijdenbord.png Stop doxepin
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start mirtazapine
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose mirtazapine = 15 mg
  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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