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Fluvoxamine-maprotiline

531 bytes removed, 14:00, 30 June 2023
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* '''Day 0:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 25 mg/day. {{TCAdecrease25p3d}}
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Caution is necessary.* '''Day 1:''' simultaneously start administration of maprotiline in a low dosage of 25-75 mg/day.* '''Day 8:''' stop administration of fluvoxamine and continue administration of maprotiline. If necessary, increase dosage of maprotiline.{{TCAincrease25p3d}}| info = * Fluvoxamine slows the metabolism of maprotiline via CYP1A2 and CYP2D6.* "Start low, go slow" is not required, but caution is necessary.* {{theorSSTCAplasmalevelmonitoring}}
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