Difference between revisions of "Mirtazapine-dosulepine"

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| to = dosulepine  
 
| to = dosulepine  
 
| stop =  
 
| stop =  
* '''Day 0:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
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{{TCAdecrease25p3d}}
* '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day.
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| start =  
| start =
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{{TCAincrease25p3d}}
No wash-out period is needed.
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| info =
* '''Day 1:''' simultaneously start administration of dosulepine in a dosage of 50-75 mg/day.
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{{TCAplasmalevelmonitoring}}
* '''Day 8:''' stop administration of mirtazapine and continue administration of dosulepine. If necessary, increase dosage of dosulepine.
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}}
* "Start low, go slow" is not required, but caution is necessary.}}
 

Latest revision as of 13:02, 30 June 2023

Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine
dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Switch medication from mirtazapine to dosulepine.[1] [2]

Nietinrijdenbord.png Stop mirtazapine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start dosulepine
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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