624
edits
Changes
no edit summary
| from = paroxetine
| to = amitriptyline
| stop = * '''Before day 1:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day. * '''Day 1:''' reduce dosage of paroxetine to a maximum of 10 mg/day. * '''Day 8:''' stop administration of paroxetine {{StopSSRI,SNRI}}
| start =
* '''Day 81:''' start administration of amitriptyline in a low dosage of 25-50 mg25mg/day. * '''Day 158:''' if necessary increase dosage of amitriptyline to a dosage of 50-100 mg/day.
| info =
* Paroxetine slows the metabolism of amitriptyline via CYP2D6inhibition. * {{SSCYPinh}}* {{TCAplasmalevelmonitoring}}
}}