Difference between revisions of "Paroxetine-doxepine"
From Psychiatrienet
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| from = paroxetine | | from = paroxetine | ||
| to = doxepin | | to = doxepin | ||
| − | | stop = | + | | stop = {{StopSSRI,SNRI}} |
| − | |||
| − | |||
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| start = | | start = | ||
| − | + | * '''Day 1:''' start administration of doxepinne in a low dosage of 25mg/day. | |
| − | * '''Day | + | * '''Day 8:''' increase dosage of doxepine to a dosage of 75 mg/day. |
| − | * '''Day | + | | info = |
| − | + | * Paroxetine slows the metabolism of doxepine via CYP2D6 inhibition. | |
| + | * {{SSCYPinh}} | ||
| + | * {{TCAplasmalevelmonitoring}} | ||
}} | }} | ||
Latest revision as of 14:33, 30 June 2023
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Switch medication from paroxetine to doxepin.[2] [3]
Stop paroxetine - Day 1: Decrease dose to 50%
- Day 8: Stop
Start doxepin- Day 1: start administration of doxepinne in a low dosage of 25mg/day.
- Day 8: increase dosage of doxepine to a dosage of 75 mg/day.
More information- Paroxetine slows the metabolism of doxepine via CYP2D6 inhibition.
- Due to CYP inhibition a longer period of time is needed to reach steady state concentration. Please keep in mind when monitoring plasma levels
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[4]
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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