Changes

| stop = * '''Day 0:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day. * '''Day 1:''' reduce dosage of paroxetine to a maximum of 10 mg/day. * '''Day 8:''' reduce dosage of paroxetine to 5 mg/day.{{StopSSRI,SNRI}}

Caution is necessary.* '''Day 81:''' simultaneously start administration of imipramine in a low dosage of 25 mg25mg/day. * '''Day 158:''' stop administration of paroxetine and only continue administration increase dosage of imipramine in to a dosage of 25-75 50 mg/day.* Start low, go slow!

* Paroxetine slows the metabolism of imipramine via CYP1A2 and CYP2D6inhibition. * {{SSCYPinh}}* {{TCAplasmalevelmonitoring}}}}