Difference between revisions of "Nortriptyline-paroxetine"
From Psychiatrienet
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| to = paroxetine | | to = paroxetine | ||
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| − | + | {{downNortriptyline}} | |
| − | + | | start = {{startmapnorcyp2d6}} | |
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| − | | start = | ||
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| − | * Paroxetine is a strong inhibitor of CYP2D6, which metabolizes nortriptyline. | + | * Paroxetine is a strong inhibitor of CYP2D6, which metabolizes nortriptyline. |
| + | * Safe target dose paroxetine = 20 mg | ||
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Latest revision as of 16:49, 30 June 2023
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Switch medication from nortriptyline to paroxetine.[1] [2]
Stop nortriptyline - Day 1: reduce dosage to 50%.
- Day 8: stop
Start paroxetine- Day 8: Start with 50% of the target dose
- Day 15: Increase dose to 100% of the target dose
- Day 16 and after: Gradually increase dose as necessary
More information- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes nortriptyline.
- Safe target dose paroxetine = 20 mg
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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