Difference between revisions of "Bupropion-amitriptyline"
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| to = amitriptyline | | to = amitriptyline | ||
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| start = | | start = | ||
| − | * '''Day 1 | + | * '''Day 1:''' Start amitriptyline with a dosage of 25 mg/day. |
| − | * '''Day | + | * '''Day 8:''' increase dosage of amitriptyline to a dosage of 50 mg/day. |
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| info = | | info = | ||
* Bupropion slows the metabolism of amitriptyline via CYP2D6. | * Bupropion slows the metabolism of amitriptyline via CYP2D6. | ||
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* {{RiskSeizureBupropionTCA}} | * {{RiskSeizureBupropionTCA}} | ||
| + | * {{TCAplasmalevelmonitoring}} | ||
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Latest revision as of 10:56, 4 August 2023
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Switch medication from bupropion to amitriptyline.[1] [2]
Stop bupropion - Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.[3]
Start amitriptyline- Day 1: Start amitriptyline with a dosage of 25 mg/day.
- Day 8: increase dosage of amitriptyline to a dosage of 50 mg/day.
More information- Bupropion slows the metabolism of amitriptyline via CYP2D6.
- The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[4]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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