Difference between revisions of "Bupropion-doxepine"
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{{Drugswitch | {{Drugswitch | ||
| from = bupropion | | from = bupropion | ||
| − | | to = | + | | to = doxepine |
| stop = | | stop = | ||
| − | + | {{StopBupropion}} | |
| − | |||
| start = | | start = | ||
| − | * '''Day 1 | + | * '''Day 1:''' start administration of doxepin in a low dosage of 25mg/day. |
| − | * '''Day | + | * '''Day 8:''' increase dosage of doxepin to a dosage of 75 mg/day. |
| + | |||
| info = | | info = | ||
* Bupropion slows the metabolism of doxepin via CYP2D6. | * Bupropion slows the metabolism of doxepin via CYP2D6. | ||
| − | |||
* {{RiskSeizureBupropionTCA}} | * {{RiskSeizureBupropionTCA}} | ||
| + | * {{TCAplasmalevelmonitoring}} | ||
}} | }} | ||
Latest revision as of 11:32, 4 August 2023
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Switch medication from bupropion to doxepine.[2] [3]
Stop bupropion - Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.[4]
Start doxepine- Day 1: start administration of doxepin in a low dosage of 25mg/day.
- Day 8: increase dosage of doxepin to a dosage of 75 mg/day.
More information- Bupropion slows the metabolism of doxepin via CYP2D6.
- The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[5]
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
- ↑ (dutch) monografie.org tricyclische-antidepressiva
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