Difference between revisions of "Vortioxetine-fluoxetine"
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| to = fluoxetine | | to = fluoxetine | ||
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* A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition. | * A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition. | ||
− | * '''Day | + | * '''Day 23:''' start administration of fluoxetine in a normal dosage of 20 mg/day. |
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| info = | | info = | ||
− | * | + | * {{theorSS}} |
− | * Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }} | + | * Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. |
+ | <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref> }} |
Latest revision as of 15:05, 4 November 2015
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Switch medication from vortioxetine to fluoxetine.[1] [2]
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
- A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition.
- Day 23: start administration of fluoxetine in a normal dosage of 20 mg/day.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "vortioxetine" (Dutch)
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